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Chunmei Yang, Xiaojing Ma, Congcong Zhang
This research explores how using a birthing ball alongside free positioning enhances the childbirth experience and outcomes for first-time mothers. A randomized controlled trial was conducted involving 200 nulliparous women, equally divided into an intervention group utilizing both birthing balls and free positions, and a control group following conventional supine delivery methods. Findings revealed that the intervention group experienced a notably shorter first stage of labor, averaging 5.8 hours compared to the control group's 7.2 hours. Additionally, the incidence of perineal injuries was reduced to 25% versus 41% in the control group. Pain levels, measured by VAS scores, were significantly lower at 6.2 points compared to 7.5 points in the control group. Maternal satisfaction rates also improved, reaching 82% in the intervention group against 65% in the control group. These results demonstrate that integrating birthing balls with free positioning effectively shortens labor duration, decreases perineal trauma, alleviates pain, and boosts maternal satisfaction, highlighting its clinical applicability. The study offers valuable scientific evidence and practical insights for optimizing delivery experiences among nulliparous women.
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Mingming Song, Yunxi Yang, Bingwei Sun
Through the clinical analysis of wound edge samples of patients with chronic infectious wounds, we found that there were a good deal of acute and chronic inflammatory cells infiltrating around the wound edge of chronic wounds, most of which were neutrophils. Prior investigations have demonstrated the apoptosis of neutrophils is significantly delayed in the state of infection, and a good deal of neutrophils with delayed apoptosis gather around the wound. Whether it will affect the wound healing has not been fully clarified. In this study, we used PIM kinase inhibitor to promote the apoptosis of neutrophils and thus promote the wound healing by making infected wounds in rats. After LPS stimulation of the rat's back wound, the neutrophils at the edge of the wound infiltrated a lot, the expression profile of CD31 decreased significantly, and the expression of PIM kinase and inflammatory factors at the edge of the wound increased significantly; After the use of PIM kinase inhibitor, the expression of CD31 at the wound margin increased significantly, and the expression of PIM kinase and inflammatory factors at the wound margin decreased significantly. LPS stimulation of neutrophil delayed apoptosis can inhibit the proliferation of HMEC1; The use of PIM447 can promote the apoptosis of neutrophils and thus the proliferation of HMEC1. The mechanism study found that LPS can promote the expression of Bcl2 and downregulate the transcriptional profile of BAX and Caspase3 via the Bcl2/Caspase3 signaling pathway, thereby facilitating the expression of PIM kinase. Our data shows that: LPS can delay neutrophil apoptosis in infectious wounds caused by Gram-negative bacteria, resulting in a large amount of neutrophil infiltration at the wound margin, which inhibits the proliferation of endothelial cells. The mechanism by which LPS inhibits neutrophil apoptosis may involve promoting the expression of neutrophil PIM kinase and regulating the Bcl2/Caspase3 pathway.
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Yuqian Zhao, Jing An, Huaqing Liu, Huiqin Ding
Objective This study aimed to explore the effect of structured psychological nursing intervention based on psychological capital theory on the psychological state of patients in the Intensive Care Unit (ICU) and the mental health of their families. Methods A randomized controlled trial design was adopted. A total of 120 conscious patients with an expected length of stay in the ICU of ≥7 days and 240 primary caregiving family members admitted to the ICU of a Grade A tertiary hospital from January to December 2023 were selected as the research subjects. They were randomly divided into an intervention group and a control group, with 60 patients and 120 family members in each group. The control group received conventional psychological nursing, while the intervention group implemented a structured psychological nursing intervention program based on psychological capital theory in addition to conventional nursing. Evidence-based nursing techniques such as goal-setting technology, cognitive restructuring method, positive suggestion therapy, and stress coping training were adopted. Each intervention lasted for 30-45 minutes, was conducted once every other day, and a total of 6 interventions were carried out. The intervention period was from 48 hours after admission to the ICU until before transfer out of the ICU. Results After the intervention, the score of the Psychological Capital Questionnaire of patients in the intervention group was significantly higher than that in the control group (42.85±6.12 vs 36.24±5.78, P<0.001), and the scores of the Hamilton Anxiety Scale and Hamilton Depression Scale were significantly lower (Anxiety: 8.45±3.21 vs 12.67±4.15, P<0.001; Depression: 7.92±2.89 vs 11.43±3.67, P<0.001). The psychological capital score of family members in the intervention group was significantly higher than that in the control group (45.76±7.23 vs 38.92±6.45, P<0.001), and the score of the Zarit Caregiver Burden Interview was significantly lower (28.34±5.67 vs 35.28±6.92, P<0.001). Conclusion The structured psychological nursing intervention based on psychological capital theory can effectively improve the mental health status of ICU patients and their families, and enhance their psychological adaptability and coping efficacy.
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Yifei Wang, Tao Lv, Xu Zhang, Hao tian
Background and Aim: Acupuncture promoting bone mass has long been applied to the treatment of osteoporosis. The aim of this study was to evaluate the protective effects of low-level laser therapy on bone loss to provide new insight into its therapeutic utility for postmenopausal osteoporosis. Experimental procedure: 24 female rats were randomly divided into 4 groups: sham operation (sham), ovariectomy (OVX), ovariectomy with needle acupuncture (O-N), and ovariectomy with laser acupuncture (O-L). O-N received needle acupuncture on the acupoints of Shenshu (BL23), Housanli (ST36) and Xuanzhong (GB39), whereas O-L received laser acupuncture on the same points. After the treatment period ended, the rats were euthanized to evaluate bone mass, microstructure, by micro-CT and histological staining. The transcription of bone formation-related genes by RT-PCR. Markers of bone metabolism was determined in serum were quantified by ELISA. Results and conclusion: O-L induced significant improvements in bone density and trabecular microarchitecture, showing significant increase in BMD, Tb.Th, Tb.N, BV/TV and Conn.D, as well as significant decline in Tb.Sp and SMI. The results mirrored the findings obtained from histological examination. Moreover, O-N versus O-L, Col-1 in O-L significant increase (P<0.05). Both forms of acupuncture treatment significantly stimulated the transcription of ALP, BMP, OCN, Col-1, RUNX- 2 and OPG. Laser acupuncture can mitigate bone loss, stimulate osteogenesis, and repair damaged trabecular network in ovariectomized rats. These results provided preliminary evidence that laser acupuncture could be applied as a non-invasive method to osteoporosis treatment.
